Provider-guided programs, 100% online. Shipped from licensed US pharmacies.

MOTS-c Injection by Awesentials, illustrative packaging

Product image is illustrative. Packaging may differ.

Peptide program · Energy and metabolism

MOTS-c InjectionRx

A compounded mitochondrial peptide, prescribed only after an online visit with a licensed provider.

$345/monthor $725 per quarter

Includes the online visit, licensed provider review, medication and shipping.

Request your visit

Online visits are opening soon. Join the list and we will contact you when they open.

MOTS-c is a mitochondrial-derived peptide, a short chain of 16 amino acids coded by the DNA inside mitochondria. It is studied, mostly in animals, for its role in cellular energy and glucose use. Through Awesentials it is compounded by a licensed US pharmacy and prescribed only when a licensed provider decides it is appropriate.

What it is
A mitochondrial-derived peptide
Strength
2 mg/mL
Supply
5 mL monthly, 15 mL quarterly
Route
Subcutaneous injection
Dispensed by
A licensed US compounding pharmacy
What's included
  • Online visit and licensed provider review
  • Compounded medication from a licensed US pharmacy, with pharmacy instructions
  • Cold-chain shipping to your door
  • Ongoing provider messaging in the patient portal
Possible side effects

Injection-site redness, itching, swelling or bruising are the most commonly reported effects; headache, nausea, flushing and tiredness are reported less often. Allergic reactions are possible. Long-term safety in people has not been established. Tell your provider about every medication and supplement you take, any history of cancer, and any medical condition. Changes in blood sugar are possible, especially with diabetes medication.

Shipping and cancellation

Ships from a licensed US pharmacy in discreet packaging, temperature-controlled where required. Cancel any time in your patient portal before the next billing date. See the Shipping Policy and Refund Policy.

Important Safety Information

Awesentials provides no medical services. All care is provided by licensed providers through an independent clinical partner. This is a compounded medication prepared by a licensed US pharmacy for an individual patient on a provider's prescription. Compounded medications are not FDA-approved and have not been reviewed by the FDA for safety, effectiveness or quality. Individual results vary and no outcome is promised. 18+ only.

Peptide programs: Peptides in this program are compounded by a licensed US pharmacy for an individual patient. They are not FDA-approved, most research on them comes from lab and animal studies, and evidence in people is limited. No result is promised. BPC-157, TB-500 (thymosin beta-4 fragments) and MOTS-c are on the World Anti-Doping Agency (WADA) Prohibited List. If you compete in a tested sport, check your sport's anti-doping rules and talk to your provider before starting.

This product is available only by prescription after an online visit with a licensed provider, who decides whether it is appropriate for you based on your medical history. Do not use if you are pregnant, breastfeeding, or allergic to any ingredient. Tell your provider about every medication, supplement and condition. Stop and seek care immediately if you have a severe reaction; call 911 in an emergency. Read more.

Learn more: MOTS-c and BPC-157 explained: what the research says

Pairs with lab panels (coming soon): Everyday health and energy

MOTS-c, in plain words

Meet the peptide your mitochondria make.

What it is in 10 seconds

MOTS-c is a small peptide coded by your mitochondria, the energy centers inside your cells. Researchers study it for how cells use energy and sugar. Most research is in animals, and a licensed provider decides whether it fits you.

Studied for

  • Cellular energy metabolism
  • How muscle uses glucose
  • Exercise capacity in animal studies

Research areas, not promised results. Most studies are in labs or animals, and evidence in people is limited.

Not for you if

  • Pregnant, breastfeeding or trying to conceive
  • Active cancer or a history of cancer
  • Under 18
  • Competing in a sport that tests under WADA rules
  • Taking insulin or blood sugar medication without your provider's approval

Your licensed provider reviews your full history and makes the final decision.

How it works, simply

  1. Made in mitochondria

    MOTS-c is coded by mitochondrial DNA rather than the DNA in the cell nucleus, which made its discovery in 2015 a surprise.

  2. Acts as a signal

    In lab and animal studies it acts on AMPK, a sensor cells use to balance energy.

  3. Studied with exercise

    Some studies find levels rise with exercise, which is why it is studied alongside activity, not instead of it.

Good to know

Myth

MOTS-c is a fat burner.

Fact

No. Research on weight and metabolism is mostly in animals, and no result is promised.

Myth

It replaces exercise.

Fact

No. It is studied alongside activity, not instead of it.

Myth

It is safe with any medication.

Fact

Not necessarily. If you take insulin or medication that lowers blood sugar, your provider needs to know first.

Opening soon

Request your MOTS-c visit

Online visits open soon. Leave your details and we will contact you as soon as they do.

  • No payment and no obligation to join the list.
  • When visits open, you complete a 10-minute online visit and a licensed provider decides what, if anything, is right for you.
  • Questions? Email support@hoolongevity.com or call (586) 321-3377, in English or Spanish.

Please do not include medical details here. Your licensed provider collects your health history during the online visit.

How it works

Three steps, all online

Every program starts and ends with a licensed provider. Awesentials handles the welcome; the clinical team handles the care.

  1. 01

    Complete a short online visit

    Answer a secure health questionnaire from your phone, about 10 minutes. No waiting room.

  2. 02

    A licensed provider reviews

    A licensed provider reviews your history and decides whether a program is appropriate. If not, you pay only the visit fee.

  3. 03

    Delivered to your door

    A licensed US pharmacy prepares your prescription and ships it in discreet packaging, with support in your patient portal.

Also available

Other essentials

FAQ

MOTS-c questions

More in the Help Center, or send us a question.

Is MOTS-c FDA-approved?

No. MOTS-c is compounded for an individual patient by a licensed US pharmacy, and compounded medications are not FDA-approved. Most research is in animals.

Will MOTS-c help me lose weight?

That has not been shown in people. Research on metabolism is mostly in animals, and no result is promised. GLP-1 programs are a separate option your provider can discuss.

How is MOTS-c taken?

As a small injection under the skin, exactly as your provider prescribes. The pharmacy includes written instructions.

Can athletes use MOTS-c?

BPC-157, TB-500 (thymosin beta-4 fragments) and MOTS-c are on the World Anti-Doping Agency (WADA) Prohibited List. If you compete in a tested sport, check your sport's anti-doping rules and talk to your provider before starting.

What does the price include?

The online visit, provider review, medication and shipping, unless a program page says otherwise. Prices may change; the price at checkout applies.

What if the provider decides treatment is not appropriate?

You pay only the visit fee. No medication ships and no subscription starts.

Are these medications FDA-approved?

The programs use compounded medications prepared by a licensed US pharmacy for an individual patient. Compounded medications are not FDA-approved.