Cellular Wellness
What is NAD+? A plain-language guide
What NAD+ is, what it does inside cells, why levels are studied in aging research, and what a prescription NAD+ program involves.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell. It shows up in conversations about wellness and aging, so it helps to know what it actually is and what is, and is not, established.
What NAD+ does in the body
Inside cells, NAD+ works as a helper molecule for enzymes. Its best-known job is in energy metabolism: it carries electrons as cells break down food to make ATP, the molecule cells use for energy. NAD+ is also used by enzymes involved in DNA repair and in signaling pathways that respond to cellular stress.
Where NAD+ comes from
The body builds NAD+ from forms of vitamin B3, such as niacin and nicotinamide, and from the amino acid tryptophan. Vitamin B3 comes from foods like poultry, fish, beef, legumes and fortified grains. Most people in the US get enough niacin from their diet.
Why researchers study NAD+ and aging
Laboratory and early human research has observed that NAD+ levels tend to fall in some tissues with age. Scientists are studying whether that decline matters for health and whether raising NAD+ changes anything meaningful. This research is ongoing, and results in cells and animals do not always carry over to people. No outcome should be expected from any NAD+ product.
What a prescription NAD+ program involves
Through Awesentials, NAD+ is a compounded injection prepared by a licensed US pharmacy for an individual patient. It is available only after a licensed provider reviews your online visit and decides whether it is appropriate. Compounded medications are not FDA-approved.
If a provider prescribes it, you receive the medication with pharmacy instructions, and you can message your provider with questions at any time.
Questions to ask your provider
- How does NAD+ fit with the medications and supplements I already take?
- What side effects should I watch for, and when should I call?
- How should I store the vial?
The bottom line
NAD+ is a real and essential coenzyme with well-understood roles in metabolism. Whether a prescription NAD+ program is right for you is a decision for you and a licensed provider, based on your own health history.
Sources
- NAD+ metabolism and its roles in cellular processes during ageing (Covarrubias et al., Nat Rev Mol Cell Biol 2021)
- Niacin, Fact Sheet for Health Professionals | NIH Office of Dietary Supplements
- Compounding and the FDA: Questions and Answers | FDA
This article is educational and does not diagnose conditions, establish eligibility for any medication, or replace care from a licensed provider. Compounded medications are not FDA-approved.
