Peptides
Sermorelin explained: what it is and how it is prescribed
Sermorelin is a lab-made version of part of a natural brain signal. Here is how it works, its history, and what to expect from a prescription program.
Sermorelin is one of the better-known peptides in wellness care. Here is what it is, where it came from, and how a prescription program works.
What sermorelin is
Sermorelin is a synthetic peptide that matches the first 29 amino acids of growth hormone-releasing hormone (GHRH). GHRH is a signal made by the hypothalamus in the brain. It tells the pituitary gland to release growth hormone in its natural pulses.
Because sermorelin acts on that upstream signal, the pituitary still controls how much growth hormone it releases. That is different from taking growth hormone itself.
A short history
A sermorelin product was approved by the FDA in the 1990s for specific uses and was later discontinued by its manufacturer. Today, sermorelin in the US is generally available as a compounded medication prepared by a licensed pharmacy for an individual patient. Compounded medications are not FDA-approved.
How it is taken
Sermorelin is usually given as a small injection under the skin. Your provider decides the dose and timing, and the pharmacy includes written instructions. Do not change your dose without talking to your provider.
Possible side effects
Injection-site pain, redness or swelling are the most commonly reported side effects. Flushing, headache and dizziness are reported less often. Tell your provider about any pituitary or thyroid condition, any history of cancer, and every medication you take. Sermorelin is not for use during pregnancy or breastfeeding.
What to expect from an Awesentials program
- Complete an online visit about your health history.
- A licensed provider reviews it and decides whether sermorelin is appropriate.
- If prescribed, a licensed US pharmacy prepares and ships it to you.
- You can message your provider in the patient portal throughout.
Results vary from person to person and no outcome is promised.
Sources
- Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? (Walker, Clin Interv Aging 2006)
- Sermorelin | PubChem, National Library of Medicine
- Compounding and the FDA: Questions and Answers | FDA
This article is educational and does not diagnose conditions, establish eligibility for any medication, or replace care from a licensed provider. Compounded medications are not FDA-approved.
